Manufacturing Shift Team Lead

About the role

AstraZeneca is building its first biologics manufacturing campus in Singapore, a USD 1.5 billion investment delivering ADC, small-molecule and large-molecule manufacturing, fill-and-finish and secondary packaging, with digital and automation infrastructure. The Manufacturing Shift Team Lead, based at the Singapore site, leads day-to-day execution of the shift production plan in a fast-moving, highly regulated environment, anticipating risks, rallying the team and delivering right-first-time batches.

Key responsibilities

• Lead the shift in line with batch records, SOPs, permits and cGMP requirements, promoting a safety-first culture and stopping unsafe operations
• Translate the production schedule into an executable shift plan, assign work by technician capability and oversee critical steps, alarms, excursions and abnormal conditions
• Run start-up and handover meetings, mentor technicians and maintain training awareness
• Ensure abnormalities are contained and documented, support root-cause analysis and CAPA closure, and support change controls, validation and inspection readiness
• Coordinate with Quality, Engineering, Safety, Warehouse, Laboratory and other teams, and drive continuous improvement on safety, yield, cycle time and reliability
• Support SOP and batch record readiness, equipment setup, FAT, SAT, commissioning and qualification, and the lifecycle management of manufacturing and containment equipment

Required profile

• Bachelor's degree or working towards a professional qualification, or a High School/Technical/Diploma with equivalent experience
• Experience in pharma or biopharma GMP manufacturing
• Strong hands-on experience in equipment troubleshooting, fault diagnosis and issue resolution in a GMP environment
• Good understanding of GMP documentation, deviation management, change control, CAPA and equipment lifecycle management
• Commitment to safety, quality and delivery in a regulated environment, with strong written and verbal communication skills

Required skills

• Desirable: Emerson Delta V, Veeva Quality Docs, SAP, Siemens PLCs
• Desirable: ADC, high containment, high potency, aseptic or other highly controlled manufacturing
• Desirable: root cause analysis, Lean Six Sigma, Single Use Systems, aseptic and automated manufacturing

The role involves in-person work, on average at least three days per week from the office, with some flexibility. The closing date is 26 October 2026.