Scientist – Nucleic Acid Biology & Therapeutics

About the role

The YUcleic Lab at GIS, A*STAR, is seeking a Scientist (or Senior Scientist) to drive innovative therapeutic strategies that target RNA and DNA. You will work at the interface of nucleic acid biology, chemical biology and functional genomics to develop antisense oligonucleotides, small‑molecule modulators and other gene‑targeting approaches.

Key responsibilities

• Design and execute mechanistic studies in disease‑relevant cellular models.
• Develop and run screening platforms to discover regulatory factors, ASOs and small molecules.
• Apply functional‑genomics and sequencing‑based methods to evaluate therapeutic activity and selectivity.
• Collaborate with biologists, chemists and computational scientists across multidisciplinary projects.
• Lead research projects, mentor junior staff and contribute to publications and grant proposals.

Required profile

• PhD in RNA biology, nucleic acid biology, functional genomics, molecular biology, pharmacology or a related field.
• Strong knowledge of RNA regulation and gene‑expression control.
• Hands‑on experience with CRISPR, CLIP‑seq, ChIP‑seq, Ribo‑seq, RNA‑seq, co‑IP, western blotting, reporter assays or cellular screening.
• Excellent scientific writing, presentation and project‑management skills.
• Independent, collaborative and motivated to explore innovative therapeutic strategies.

Required skills

• CRISPR
• CLIP‑seq
• ChIP‑seq
• Ribo‑seq
• RNA‑seq
• Co‑immunoprecipitation (co‑IP)
• Western blotting
• Reporter assays
• Cellular screening

What we offer

• Opportunity to lead high‑impact, multidisciplinary research.
• Access to world‑class genomics, sequencing and computational platforms.
• Strong support for publications, grant development and intellectual property generation.
• Collaborative environment within Singapore’s national flagship institute for genomic sciences.