Lead Scientist, Purification Development

About the role

Lonza Singapore's Purification Development team develops and characterizes downstream manufacturing processes for novel therapeutic recombinant proteins. As Lead Scientist, you provide scientific leadership for process development and characterization, act as a downstream subject matter expert and give technical support for manufacturing and regulatory submissions. The role is based at the Tuas site.

Key responsibilities

• Lead and oversee Process Development, Process Characterization and/or Viral Clearance activities, including study planning, technical supervision and interpretation of results.
• Run small-scale model studies such as risk assessments (FMEA), scale-down model qualification, Design of Experiments (DoE), resin reuse/lifetime studies and regulatory submission support.
• Lead and support purification activities, including chromatography (Affinity, Mixed-Mode, Ion Exchange) on ÄKTA/UNICORN systems, ultrafiltration/diafiltration and viral reduction studies.
• Train and mentor junior scientists and new hires in laboratory activities, purification technologies and laboratory techniques.
• Prepare and review protocols, reports, SOPs and technical documentation.
• Act as project representative for internal and external customers and coordinate multiple projects.
• Support manufacturing operations, troubleshooting and technology transfer, and contribute to safety and training initiatives.

Required profile

• Degree or PhD in Life Sciences or a related field with relevant industry experience.
• 4-7 years' experience in protein purification/process development; PhD candidates with 2-5 years' experience may also be considered.
• Strong expertise in protein purification and Process Characterization; Process Validation and/or Viral Clearance experience is advantageous.
• Understanding of cGMP/BLA requirements is preferred.

Required skills

• Protein purification and Process Characterization
• Statistical software such as JMP for DoE data analysis (highly advantageous)
• Technical writing, communication, problem-solving and analytical skills

What we offer

• Medical insurance with the option to include family members at partially subsidized premiums.
• Company transport from designated MRT stations to and from the Tuas site.
• Full employee benefits suite.
• Cross-functional projects and global exposure for professional growth.